At Skin Space, we live and breathe injectables. They’re not just what we do—they’re what we know. From smoothing forehead lines to perfecting that just-right brow lift, we’ve worked with just about every neuromodulator in the game. So when a new contender steps into the ring, you’d better believe we’re watching closely—and probably testing it out ourselves before the day’s even over.

Enter Letybo (pronounced let-ee-bo), the latest wrinkle-smoothing neurotoxin making its U.S. debut. And yes—it’s officially on our treatment menu here at Skin Space.

If you’ve never heard of Letybo before, don’t worry. We’re going to break it all down: what it is, how it compares to the big names you already know (looking at you, Botox), and why we’re pretty pumped to offer it to our clients. Spoiler: Letybo may be the underdog today, but it’s definitely not playing small.

What Is Letybo?

Let’s start with the basics: Letybo is a botulinum toxin type A injectable, just like Botox, Dysport, Xeomin, Daxxify, and Jeuveau. It works by temporarily relaxing the facial muscles that cause dynamic wrinkles (those creases that appear when you smile, frown, squint, etc.). Over time—and with consistent treatments—those lines soften and can even disappear altogether.

Letybo has been widely used across Asia and Europe for years, but it was only recently approved by the FDA for use in the U.S. in 2023. It’s manufactured by Hugel, a South Korean aesthetics powerhouse, and its entry into the American market is big news for both injectors and clients alike.

Why? Because more options mean more personalized results. And that’s something we can all get behind.

So… Is It Like Botox?

Yes and no.

Botox has been the gold standard for wrinkle prevention and treatment for decades—and for good reason. It works, it’s consistent, and most people recognize the name immediately. But here’s the thing: just like not all jeans fit the same, not all neurotoxins perform the same on everyone’s face.

New to Botox? Read our blog post: Botox 101

Here’s a side-by-side look at how Letybo stacks up against the other major players:

Neurotoxin	Onset Time	Duration	Units Needed (on average)	Unique Feature
Botox	3–5 days	3–4 months	Baseline (e.g., 20 units for frown lines)	Most well-known, FDA pioneer
Dysport	2–3 days	3–4 months	Usually more (conversion 2.5:1)	Spreads more, great for larger areas
Xeomin	3–5 days	3–4 months	Similar to Botox	“Naked” formula, no accessory proteins
Jeuveau	2–3 days	3–4 months	Similar to Botox	Marketed for cosmetic use only
Letybo	2–4 days	3–4 months	Comparable to Botox	Smooth, precise injection feel

Letybo’s onset and duration are in line with the familiar names, but what makes it interesting is the precision of placement and the smooth texture when injecting. Our injectors here at Skin Space have noted that Letybo has a certain “silkiness” to it—making it a pleasure to work with when you’re aiming for subtle, natural results.

Who Should Try Letybo?

Letybo is a great choice for:

• First-timers who want to explore wrinkle relaxers but are open to newer brands
• Regular Botox users who feel like their current results aren’t lasting as long as they used to
• People who are looking for a slightly softer, more refined finish
• Budget-conscious clients interested in trying a newer product at an introductory price (yep—we often run promotions on our new services 👀)

One important note: Letybo is currently FDA-approved for the treatment of glabellar lines (those vertical “11” lines between your eyebrows), but that doesn’t mean that’s all it can do. Like with Botox and other neuromodulators, experienced injectors—like ours at Skin Space—can use it off-label for areas like:

• Forehead lines
• Crow’s feet
• Bunny lines
• Lip flip
• Jawline slimming (masseter treatment)
• Neck bands

Letybo Before and After Photos

We Have Some Data

Clinical studies show that Letybo delivers consistently reliable results, with impressive responder rates that speak for themselves. At Week 4, 65% of participants experienced a ≥2-grade improvement from baseline and achieved a “None” or “Mild” score on the Glabellar Line Scale. According to investigator assessments, 79% of patients saw this level of improvement compared to just 1% with placebo. Subjects themselves reported a 69% improvement—again, versus 0% for placebo. Even in separate studies, Letybo met the primary efficacy endpoint with composite responder rates of 47% and 45%, confirming its ability to significantly reduce the appearance of moderate to severe frown lines with precision and reliability.

Real Talk: What Our Injectors Think

We’re kind of nerds when it comes to technique and product innovation, so we’ve been testing Letybo behind the scenes since it became available in the U.S. And the feedback has been… enthusiastic, to say the least.

Some things our injectors have loved so far:

• Predictable results: We’ve seen consistently smooth outcomes in frown line treatments.
• Low diffusion: The product stays where you place it, making it ideal for areas where precision is critical.
• Gentle feel: Patients have noted less “tightness” in the first few days post-treatment compared to other injectables.

And best of all? Happy clients who are thrilled with their refreshed, not-frozen look.

Is Letybo Better Than Botox?

This is the million-dollar question—and the honest answer is: it depends on your face.

Botox has the legacy and trust of being the first on the market. It works, it lasts, and it’s a known quantity.

But Letybo offers a fresh alternative with a few key advantages:

• Some patients report a softer, more natural feel with less of that “frozen” sensation early on.
• It may offer more precise targeting for microinjections, especially in delicate areas.
• For clients who’ve used Botox for years, Letybo can be a welcome change that gives your muscles a slightly different response—sometimes just enough to keep things working optimally again.

We’re not saying Letybo will replace Botox, but we are saying it earns its spot on the shelf.

Jeuveau, Xeomin, Dysport—Where Does Letybo Fit In?

Think of it like this:

• Jeuveau is the flirty Instagram influencer of the group—fun, trendy, and great at branding.
• Xeomin is the clean beauty minimalist—no extras, just the basics.
• Dysport is the athlete—fast-acting and great for large muscle groups.
• Botox is the OG—trusted, tried, and true.
• Letybo? It’s the cool, quietly confident newcomer. A little under-the-radar right now, but those in the know are paying attention.

The Bottom Line: Should You Try Letybo?

If you’ve been thinking about dipping your toes into the injectable world—or if you’re just ready to try something new—Letybo is 100% worth considering. It’s effective, smooth, and already winning over both injectors and patients across the country.

At Skin Space, we’re proud to offer Letybo injections in Massapequa, NY, because we believe in giving our clients access to the best of what’s available in aesthetics. Our experienced team will walk you through your options, explain how Letybo compares to what you may have tried in the past, and customize a plan that fits your unique goals and facial anatomy.

Ready to Give It a Shot?

(Sorry, we had to.)

Whether you’re a Botox loyalist, a Dysport devotee, or a curious newbie, we’d love to talk more about whether Letybo is right for you. Come see us at Skin Space and experience the difference for yourself.

Smooth skin is in. Let’s find the right wrinkle relaxer for you—Letybo included.

Book your consultation today with Skin Space and let our team of experts help you look refreshed, confident, and totally you.